In New York, Cindy Campbell (Anna Faris) visits her brother-in-law Tom Logan (Charlie Sheen). Since the previous film, her husband George has died and her nephew Cody has been sent to military school, leaving her a broken and lonely woman. Tom, equally depressed despite being in a relationship with three girls, tries to commit suicide by overdosing on sleeping pills. However, he mistakenly ingests Viagra, resulting in a painful death when he tumbles over the balustrade and lands on his absurdly erect penis.